Interesting you said "new tires"...
They stock size? Rims?
Usually new tires is a couple mpg hit...more rubber, more squirm, and slightly bigger diameter....plus the cheapest or ones that give you super long life can be worse. Not saying it's all you problem, mpg issues can be a death by a thousand cuts....
One dragging brake.... roof rack... slightly wider tires.... Heavy aftermarket rims that can sometimes make extra drag (yes big open style rims for cooling)....sometimes plastic air dam parts missing or broken, driving style, fuel....look at the details...lots of little issues equal a big issue
Good luck....