In my opinion, steady state highway driving will require less wear and tear from the transaxle, simply because it will have less to do. Fewer gear changes mean fewer movements of everything in that box.
The thing that seems to be the worst for these automagic boxes though, is the belief in VW's marketing BS. You know, the one that claimed the 01M has a lifetime fluid so you never had to change it. The people that have had one run hundreds of thousands of miles without trouble didn't abuse them and changed the fluid and filter regularly. How you tell what the maintenance history is for an example you are trying to buy would be difficult at best, unless the seller can produce proper paperwork. But even then, there have been so many examples of professional mechanic screwups on this forum, and from dealers no less, that I would wonder even then. Maybe if I draw a fluid sample to see the color and do it while the engine is running so I could tell whether the fluid level was adequate then maybe I'd believe the claim.
But with the history of these things, it is hard to have a lot of faith that everything will be all sweetness and light as the seller will represent.
Good luck!
Cheers,
PH