To a point, yes. But how much? I am doing a little experiment now myself. My Golf normally gets around 50, I've tracked the last 5 tankfuls and my average has been 49.4. I drive fast, 80+ usually... with dips into triple digits pretty regularly.
I've decided to slow down and stay at the speed limit, which is 70 for most of my drive. It isn't easy, to be honest, hanging out with the Priuses and being swerved around and passed by everything else... so I won't continue this craziness beyond my experiment. But, we'll see just how much better my car can get... I'm only about 300 miles into my first "70-max" tank, though.
Thing is, it now takes me 10 minutes longer to get to work, sometimes 15 minutes (because I can't easily zip around the even-slower-than-70 Prius asshats without exceeded my own 70 limit or blocking up the normal people doing 80).
By the end of it, I'm sure any fuel savings will be forgotten by non-productive time on the road versus being to the shop and actually earning money instead. So for now, we'll see how it goes... I'm shooting for a 60 MPG tank, but I doubt I'll get that high, and I don't know if I can do this beyond just one tank's worth of driving.