Bear in mind that your vehicle is going to be your mobile home. If small kids are there, childproof accordingly. Tune up your car for smooth sailing. NHTSA recommends travelers to have tires, battery, belts, fluids and air conditioners duly checked by a professional mechanic.
Do check for road safety tips at
http://universe.byu.edu/2017/05/02/tips-and-tricks-for-a-safe-and-successful-road-trip/
I would suggest you get a panzar plate for the engine, basic tools, extra spare tire (same size as your vehicle).
Also make arrangements for the spare fuel filter, extra cell phone chargers, credit cards with lots of credit
battery.
Try avoiding the rainy season. Secure your home before the trip. Fortify your homes with
window and door security bar. Place a hold on mail, newspaper and other deliveries when you are away. Hire a lawn care company. And get motion detectors installed.
Go with the best network service available. Ham Radio might come in handy. Carry windshield cleaner, a gallon or two of water, air pump with a bottle of slime.
Get a good night's sleep for safe driving and switch between adults. Get your car booster seats checked for correct installation. Gear yourself for safety with the emergency kit which includes water, warm blankets, a flashlight, jumper cables, flares, tools to change a tire, a fully charged cell phone, a first aid kit. Check for smoking hazards.
Do share your experience and let us know about your trip.
While driving, ignore phone calls, take a long view and look away from lights.