If fixed my high pitch/variable w/acceleration whine just now with a $8 noise filter between switched power and the head unit ignition power wire+(aftermarket) powered sub in the spare tire.
I used the choke/coil style off of Amazon:
Noise Filter
It's a 95% reduction and I'm so relieved.
Previously multiple grounds, single common ground, grounding chassis/head unit/RCA negative side together, and clip-on ferrite chokes on every conceivable power line with multiple combinations of choke sizes were all tried and all did nothing.
I also tried multiple iterations of RCA ground loop isolators, and while they stopped any whine from the aftermarket sub amp, they also reduced sound output to just a fraction what was put out before. The whine from the head unit/door speakers remained.
I'm looking forward to a long drive this week to see if, after years of getting used to it, the whine is truly gone.